Conventional drug delivery systems require periodic doses of the therapeutic agent to produce maximum therapeutic effect. For most drugs, conventional methods of drug administration are effective, except for some drugs which are unstable or toxic, narrow therapeutic window or some solubility problems, low half life. Aceclofenac is having very less aqueous solubility and certain side effects like gastric irritation, ulcer, temporal headache, low half life, poor flow properties, compression characteristics etc, so encapsulation of it into microsponge would improve its solubility, protect the gastrointestinal mucosa from direct exposure to drug and lower plasma levels by retarding and controlling the release rate and also improve flow properties and compression characteristics. In this study microsponges were prepared by emulsion solvent diffusion technique using ethyl cellulose, eudragit S100, eudragit RS100, eudragit RL100 and evaluated for % production yield, % loading efficiency and in-vitro drug release. Amorphization of drug into microsponge was confirmed by DSC. Controlled release tablets were prepared from optimized batch of microsponge by direct compression and then the prepared tablets were evaluated for hardness, friability, weight variation and in-vitro drug release study.
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